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Dissecting the Genetic and Proteomic Risk Factors for Delirium | medRxiv | Raptis V, Bhak Y, Cannings TI, et al. | 2024 |
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Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid-Related Loci as the Main Driver of Opioid Use Disorder. | Genet Epidemiol | Annis AC, Gunaseelan V, Smith AV, et al. | 2024 |
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Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome. | Nat Genet | Park S, Kim S, Kim B, et al. | 2024 |
Sex-specific genetic architecture of blood pressure. | Nat Med | Yang M-L, Xu C, Gupte T, et al. | 2024 |
Potential association of SULT2A1 and ABCG2 variant alleles with increased risk for palbociclib toxicity. | Pharmacogenomics | Wang C, Hwang M, Paulson B, et al. | 2024 |
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology | Nature | Suzuki K, Hatzikotoulas K, Southam L, et al. | 2024 |
Polygenic Score for the Prediction of Postoperative Nausea and Vomiting: A Retrospective Derivation and Validation Cohort Study. Anesthesiology | Anesthesiology | Douville NJ, Bastarache L, He J, et al. | 2024 |
Investigating the association between gut microbiome and aortic aneurysm diseases: a bidirectional two-sample Mendelian randomization analysis | Front Cell Infect Microbiol | Sun Y, Dong H, Sun C, et al. | 2024 |
Associations Between Genetically Predicted Iron Status and Cardiovascular Disease Risk: A Mendelian Randomization Study | J Am Heart Assoc. | Barad A, Clark AG, Pressman EK, et al. | 2024 |
The Influence of Autoimmune Thyroid Diseases on Viral Pneumonia Development, Including COVID-19: A Two-Sample Mendelian Randomization Study | Pathogens | Yi K, Tian M, Li X. | 2024 |
Connecting atrial fibrillation to digestive neoplasms: exploring mediation via ischemic stroke and heart failure in Mendelian randomization studies | Front Oncol | Xu Z, Rao X, Xing Y, et al. | 2024 |
Risk of Toxicity From Topical 5-Fluorouracil Treatment in Patients Carrying DPYD Variant Alleles | Clin Pharmacol Ther | Granados J, Pasternak AL, Henry NL, et al. | 2024 |
Automated-detection of risky alcohol use prior to surgery using natural language processing | Alcohol Clin Exp Res | Vydiswaran VGV, Strayhorn A, Weber K, et al. | 2024 |
Associations between metabolic hyperferritinaemia, fibrosis-promoting alleles and clinical outcomes in steatotic liver disease | Liver Int | Suresh D, Li A, Miller MJ, et al. | 2024 |
Risk scores for major bleeding from direct oral anticoagulants: comparing predictive performance in patients with atrial fibrillation | Res Pract Thromb Haemost | Campos-Staffico AM, Jacoby JP, Dorsch MP, et al. | 2024 |
Multi-Ancestry Polygenic Risk Scores for Venous Thromboembolism. | medRxiv | Jee YH, Thibord F, Dominguez A, et al. | 2024 |
Hemorrhoidal disease and its genetic association with depression, bipolar disorder, anxiety disorders, and schizophrenia: a bidirectional mendelian randomization study | Hum Genomics | Huang Z, Huang J, Leung CK, et al. | 2024 |
Clinical associations with a polygenic predisposition to benign lower white blood cell counts | Nat Commun | Mosley JD, Shelley JP, Dickson AL, et al. | 2024 |
A framework for understanding selection bias in real-world healthcare data | J R Stat Soc Ser A | Kundu R, Shi X, Morrison J, et al. | 2024 |
Incorporating functional annotation with bilevel continuous shrinkage for polygenic risk prediction | BMC Bioinformatics | Zhuang Y, Kim NY, Fritsche LG, et al. | 2024 |
Plasma adiponectin levels and risk of heart failure, atrial fibrillation, aortic valve stenosis, and myocardial infarction: large-scale observational and Mendelian randomization evidence | Cardiovasc Res | Nielsen MB, Çolak Y, Benn M, et al. | 2024 |
Genetic Liability to Posttraumatic Stress Disorder Symptoms and Its Association With Cardiometabolic and Respiratory Outcomes | JAMA Psychiatry | Pathak GA, Singh K, Choi KW, et al. | 2024 |
Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank | Nat Genet | Oliveri A, Rebernick RJ, Kuppa A, et al. | 2024 |
To weight or not to weight? The effect of selection bias in 3 large electronic health record-linked biobanks and recommendations for practice | J Am Med Inform Assoc | Salvatore M, Kundu R, Shi X, et al. | 2024 |
A genome-wide association study of susceptibility to upper urinary tract infections | J Infect Dis | Flatby HM, Ravi A, Liyanarachi KV, et al. | 2024 |
Assessing the Clinical Utility of Published Prostate Cancer Polygenic Risk Scores in a Large Biobank Data Set | Eur Urol Oncol | Vince RA, Sun H, Singhal U, et al. | 2024 |
Association between nociplastic pain and premature endocrine therapy discontinuation in breast cancer patients. | Breast Cancer Res Treat | Joyce E, Carr G, Wang S, et al. | 2023 |
Confirmatory DPYD Testing in Patients Receiving Fluoropyrimidines Who are Suspected DPYD Variant Carriers Based on a Genetic Data Repository | Clin Pharmacol Ther | Pasternak AL, Seda R, Lipa J, et al. | 2023 |
Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran Program | Nat Genet | Klarin D, Devineni P, Sendamarai AK, et al. | 2023 |
Mendelian randomization study of thyroid function and anti-Müllerian hormone levels | Front Endocrinol | Liang Z, Xu Z, Liu J. | 2023 |
Polygenic prediction of preeclampsia and gestational hypertension. | Nat Med | Honigberg MC, Truong B, Khan RR, et al. | 2023 |
Progression to cirrhosis is similar among all ages in nonalcoholic fatty liver disease, but liver-related events increase with age | Hepatol Commun | Miller MJ, Harding-Theobald E, DiBattista JV, et al. | 2023 |
Proteome‐Wide Mendelian Randomization Analysis Identified Potential Drug Targets for Atrial Fibrillation | J Am Heart Assoc | Wang X, Huang T, Jia J. | 2023 |
Major Genetic Risk Factors for Dupuytren’s Disease Are Inherited From Neandertals | MBE | Ågren R, Patil S, Zhou X, et al. | 2023 |
Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture | Nat Commun | Hao X, Shao Z, Zhang N, et al. | 2023 |
Multi-ancestry meta-analysis identifies 5 novel loci for ischemic stroke and reveals heterogeneity of effects between sexes and ancestries | Cell Genom | Surakka I, Wu K-H, Hornsby W, et al. | 2023 |
Risk Variants in or Near ZBTB40 AND NFATC1 Increase the Risk of Both IBD and Adverse Bone Health Outcomes Highlighting Common Genetic Underpinnings Across Both Diseases | Inflamm Bowel Dis | Cushing KC, Chen Y, Du X, et al. | 2023 |
Epidemiologic Questionnaire (EPI-Q) – a scalable, app-based health survey linked to electronic health record and genotype data | Epidemiol Health | Salvatore M, Clark-Boucher D, Fritsche LG, et al. | 2023 |
A pilot genome-wide association study meta-analysis of gastroparesis | United European Gastroenterol J | Tavares LC, Zheng T, Kwicklis M, et al. | 2023 |
PNPLA3 Risk Allele Association With ALT Response to Semaglutide Treatment | Gastroenterology | Urias E, Tedesco NR, Oliveri A, et al. | 2023 |
Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanks | PLoS Genet | Fritsche LG, Nam K, Du J, et al. | 2023 |
Predicting persistent opioid use after hand surgery: a machine learning approach | Plast Reconstr Surg | Baxter NB, Ho AZ, Byrd JN, et al. | 2023 |
Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver disease | Nat Genet | Chen Y, Du X, Kuppa A, et al. | 2023 |
Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus | Nat Commun | Khunsriraksakul C, Li Q, Markus H, et al. | 2023 |
Evaluation of polygenic risk scores to differentiate between type 1 and type 2 diabetes | Genet Epidemiol | Shoaib M, Ye Q, IglayReger H, et al. | 2023 |
PNPLA3 Genotype and Diabetes Identify Patients With Nonalcoholic Fatty Liver Disease at High Risk of Incident Cirrhosis | Gastroenterology | Chen VL, Oliveri A, Miller MJ, et al. | 2023 |
Identifying the prevalence of clinically actionable drug-gene interactions in a health system biorepository to guide pharmacogenetics implementation services | Clin Transl Sci | Pasternak AL, Ward K, Irwin M, et al. | 2023 |
Association of ALDH1A1 Polymorphism With Toxicity From Cyclophosphamide Treatment | Research Square | Hwang M, Medley S, Shakeel F, et al. | 2022 |
Lack of association of CYP2B6 pharmacogenetics with cyclophosphamide toxicity in patients with cancer | Support Care Cancer | Hwang M, Medley S, Shakeel F, et al. | 2022 |
Meta-analysis fine-mapping is often miscalibrated at single-variant resolution | Cell Genom | Kanai M, Elzur R, Zhou W, et al. | 2022 |
Eight pharmacokinetic genetic variants are not associated with the risk of bleeding from direct oral anticoagulants in non-valvular atrial fibrillation patients | Front Pharmacol | Campos-Staffico AM, Dorsch MP, Barnes GD, et al. | 2022 |
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis | Genome Biol | Kanoni S, Graham SE, Wang Y, et al. | 2022 |
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals | Commun Biol | Winkler TW, Rasheed H, Teumer A, et al. | 2022 |
COVID-19 and Thyroid Function: A Bi-Directional Two-Sample Mendelian Randomization Study | Thyroid | Li GH-Y, Tang C-M, Cheung C-L. | 2022 |
Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversity | Cell Genom | Tsuo K, Zhou W, Wang Y, et al. | 2022 |
The Phenotype-Genotype Reference Map: Improving biobank data science through replication | bioRxiv | Bastarache L, Delozier S, Pandit A, et al. | 2022 |
The Michigan Genomics Initiative: A biobank linking genotypes and electronic clinical records in Michigan Medicine patients | Cell Genom | Zawistowski M, Fritsche LG, Pandit A, et al. | 2022 |
Leveraging global multi-ancestry meta-analysis in the study of idiopathic pulmonary fibrosis genetics | Cell Genom | Partanen JJ, Häppölä P, Zhou W, et al. | 2022 |
Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease | Cell Genom | Zhou W, Kanai M, Wu K-HH, et al. | 2022 |
ExPRSweb: An online repository with polygenic risk scores for common health-related exposures | Am J Hum Genet | Ma Y, Patil S, Zhou X, et al. | 2022 |
Genetic variants associated with sepsis | PLoS One | Engoren M, Jewell ES, Douville N, et al. | 2022 |
Impact of Pharmacogenetics on Intravenous Tacrolimus Exposure and Conversions to Oral Therapy | Transplant Cell Ther | Pasternak AL, Marcath LA, Li Y, et al. | 2022 |
A Substitution in the Glutathione Reductase Lowers Electron Leakage and Inflammation in Modern Humans | Sci Adv | Coppo L, Mishra P, Siefert N, et al. | 2022 |
The Major Genetic Risk Factor for Severe COVID-19 Is Associated with Protection against HIV | Proc Natl Acad Sci USA | Zeberg H. | 2022 |
Predicting Persistent Opioid Use after Surgery Using Electronic Health Record and Patient-Reported Data | Surgery | Singh K, Murali A, Stevens H, et al. | 2022 |
A first update on mapping the human genetic architecture of COVID-19 | Nature | Pathak GA, Karjalainen J, Stevens C, et al. | 2022 |
Polygenic Liability to Depression Is Associated With Multiple Medical Conditions in the Electronic Health Record: Phenome-Wide Association Study of 46,782 Individuals | Biol Psychiatry | Fang Y, Fritsche LG, Mukherjee B, et al. | 2022 |
Assessing the Added Value of Linking Electronic Health Records to Improve the Prediction of Self-Reported COVID-19 Testing and Diagnosis | PLoS One | Clark-Boucher D, Boss J, Salvatore M, et al. | 2022 |
Polygenic Risk Prediction in Diverticulitis | Ann Surg | De Roo AC, Chen Y, Du X, et al. | 2022 |
Genome-Wide Meta-Analysis of Iron Status Biomarkers and the Effect of Iron on All-Cause Mortality in HUNT | Commun Biol | Moksnes MR, Graham SE, Wu K-H, et al. | 2022 |
Hepatic decompensation is accelerated in patients with cirrhosis and alpha-1 antitrypsin Pi∗MZ genotype | JHEP Rep | Chen VL, Burkholder DA, Moran IJ, et al | 2022 |
Inflammatory Bowel Disease Risk Variants Are Associated with an Increased Risk of Skin Cancer | Inflamm Bowel Dis | Cushing KC, Du X, Chen Y, et al. | 2022 |
The Construction of Multi-Ethnic Polygenic Risk Score Using Transfer Learning | medRxiv | Zhao Z, Fritsche LG, Smith JA, et al. | 2022 |
SLCO1B3 Polymorphisms and Clinical Outcomes in Kidney Transplant Recipients Receiving Mycophenolate | Pharmacogenomics | Schumacher L, Fang F, Kidwell KM, et al. | 2021 |
Plasma Cortisol and Risk of Atrial Fibrillation: A Mendelian Randomization Study | J Clin Endocrinol Metab | Larsson SC, Lee W-H, Burgess S, et al. | 2021 |
The Power of Genetic Diversity in Genome-Wide Association Studies of Lipids | Nature | Graham SE, Clarke SL, Wu K-HH, et al. | 2021 |
On Cross-Ancestry Cancer Polygenic Risk Scores | PLoS Genet | Fritsche LG, Ma Y, Zhang D, et al. | 2021 |
False Discovery Rates for Genome-Wide Association Tests in Biobanks with Thousands of Phenotypes | Research Square | Annis A, Pandit A, LeFaive J, et al. | 2021 |
Exposure and risk factors for COVID-19 and the impact of staying home on Michigan residents | PLoS One | Wu K-HH, Hornsby WE, Klunder B, et al. | 2021 |
A powerful subset-based method identifies gene set associations and improves interpretation in UK Biobank | Am J Hum Genet | Dutta D, VandeHaar P, Fritsche LG, et al. | 2021 |
A survey of functional dyspepsia in 361,360 individuals: Phenotypic and genetic cross‐disease analyses | Neurogastroenterol Motil | Garcia-Etxebarria K, Carbone F, Teder-Laving M, et al. | 2021 |
Genetic association studies of fibromuscular dysplasia identify new risk loci and shared genetic basis with more common vascular diseases | Nat Commun | Georges A, Yang M-L, Berrandou T-E, et al. | 2021 |
Mapping the human genetic architecture of COVID-19 | Nature | Niemi MEK, Karjalainen J, Liao RG, et al. | 2021 |
Disclosure of clinically actionable genetic variants to thoracic aortic dissection biobank participants | BMC Med Genomics | Beil A, Hornsby W, Uhlmann WR, et al. | 2021 |
Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal disease | Gut | Zheng T, Ellinghaus D, Juzenas S, et al. | 2021 |
Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysm | Am J Hum Genet | Roychowdhury T, Lu H, Hornsby WE, et al. | 2021 |
Genome-Wide Association Study of Pelvic Organ Prolapse Using the Michigan Genomics Initiative | Female Pelvic Med Reconstr Surg | Cox CK, Pandit A, Zawistowski M, et al. | 2021 |
Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer’s disease and myocardial infarction | Hum Mol Genet | Palmer ND, Kahali B, Kuppa A, et al. | 2021 |
Patients carrying DPYD variant alleles have increased risk of severe toxicity and related treatment modifications during fluoropyrimidine chemotherapy | Pharmacogenomics | Shakeel F, Fang F, Kwon JW, et al. | 2021 |
Why are rare variants hard to impute? Coalescent models reveal theoretical limits in existing algorithms | Genetics | Si Y, Vanderwerff B, Zöllner S | 2021 |
Phenotype risk scores (PheRS) for pancreatic cancer using time-stamped electronic health record data: Discovery and validation in two large biobanks | J Biomed Inform | Salvatore M, Beesley LJ, Fritsche LG, et al. | 2021 |
Genetic mutations associated with susceptibility to perioperative complications in a longitudinal biorepository with integrated genomic and electronic health records | Br J Anaesth | Douville NJ, Kheterpal S, Engoren M, et al. | 2020 |
Use of a Polygenic Risk Score Improves Prediction of Myocardial Injury After Non-Cardiac Surgery | Circ Genom Precis Med | Douville NJ, Surakka I, Leis A, et al. | 2020 |
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer | Nat Commun | Zhou W, Brumpton B, Kabil O, et al. | 2020 |
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular disease | Nat Commun | Nielsen JB, Rom O, Surakka I, et al. | 2020 |
Chromosome 1q21. 2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction | Nat Commun | Saw J, Yang M-L, Trinder M, et al. | 2020 |
LabWAS: Novel findings and study design recommendations from a meta-analysis of clinical labs in two independent biobanks | PLoS Genet | Goldstein JA, Weinstock JS, Bastarache LA, et al. | 2020 |
Statistical inference for association studies using electronic health records: handling both selection bias and outcome misclassification | Biometrics | Beesley LJ, Mukherjee B | 2020 |
Novel score test to increase power in association test by integrating external controls | Genet Epidemiol | Li Y, Lee S | 2020 |
Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent Biobanks | Am J Hum Genet | Fritsche LG, Patil S, Beesley LJ, et al. | 2020 |
An analytic framework for exploring sampling and observation process biases in genome and phenome-wide association studies using electronic health records | Stat Med | Beesley LJ, Fritsche LG, Mukherjee B | 2020 |
Interaction analysis under misspecification of main effects: Some common mistakes and simple solutions | Stat Med | Zhang M, Yu Y, Wang S, et al. | 2020 |
The emerging landscape of health research based on biobanks linked to electronic health records: Existing resources, statistical challenges, and potential opportunities | Stat Med | Beesley LJ, Salvatore M, Fritsche LG, et al. | 2020 |
Genetic variants that associate with cirrhosis have pleiotropic effects on human traits | Liver Int | Chen VL, Chen Y, Du X, et al. | 2020 |
Heritability of the Fibromyalgia Phenotype Varies by Age | Arthritis Rheumatol | Dutta D, Brummett CM, Moser SE, et al. | 2020 |
Estimation of DNA contamination and its sources in genotyped samples | Genet Epidemiol | Zajac GJM, Fritsche LG, Weinstock JS, et al. | 2019 |
Meta-MultiSKAT: Multiple phenotype meta-analysis for region-based association test | Genet Epidemiol | Dutta D, Gagliano Taliun SA, Weinstock JS, et al. | 2019 |
Body Composition and Genetic Lipodystrophy Risk Score Associate With Nonalcoholic Fatty Liver Disease and Liver Fibrosis | Hepatol Commun | Chen VL, Wright AP, Halligan B, et al. | 2019 |
Health Care Burden Associated with Outpatient Opioid Use Following Inpatient or Outpatient Surgery | J Manag Care Spec Pharm | Brummett CM, England C, Evans-Shields J, et al. | 2019 |
Exploring various polygenic risk scores for skin cancer in the phenomes of the Michigan genomics initiative and the UK Biobank with a visual catalog: PRSWeb | PLoS Genet | Fritsche LG, Beesley LJ, VandeHaar P, et al. | 2019 |
Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysis | Nat Commun | Graham SE, Nielsen JB, Zawistowski M, et al. | 2019 |
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes | Nat Commun | Gusarova V, O’Dushlaine C, Teslovich TM, et al. | 2018 |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology | Nat Genet | Nielsen JB, Thorolfsdottir RB, Fritsche LG, et al. | 2018 |
Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease | Nat Genet | Maguire LH, Handelman SK, Du X, et al. | 2018 |
Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics Initiative | Am J Hum Genet | Fritsche LG, Gruber SB, Wu Z, et al. | 2018 |
Association of Rare Predicted Loss-of-Function Variants in Cellular Pathways with Sub-Phenotypes in Age-Related Macular Degeneration | Ophthalmology | Pietraszkiewicz A, van Asten F, Kwong A, et al. | 2018 |
Prevalence of Preoperative Opioid Use and Characteristics Associated With Opioid Use Among Patients Presenting for Surgery | JAMA Surg | Hilliard PE, Waljee J, Moser S, et al. | 2018 |
Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development | Am J Hum Genet | Nielsen JB, Fritsche LG, Zhou W, et al. | 2018 |
Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve | Nat Commun | Yang B, Zhou W, Jiao J, et al. | 2017 |
A Fast and Accurate Algorithm to Test for Binary Phenotypes and Its Application to PheWAS | Am J Hum Genet | Dey R, Schmidt EM, Abecasis GR, et al. | 2017 |