Research Impact

Our services and expertise directly empower our members to develop impactful research.

We are the leading source for enabling and accelerating groundbreaking research at the intersection of AI and health. The research we support produces novel scientific discoveries that will revolutionize the future of digital healthcare.

Impact Stories

The digital health research we support for our members is having real world impact. See examples of some of the impact below.

Emerging Innovations

We are serious about getting AI innovations to the bedside. The Emerging Innovations listed below have completed initial testing and proof-of-concept validation. Research projects that make it to the Emerging Innovation stage have high confidence for commercial viability and will be ready to license in 1-2 years.

Companies interested in sponsoring further R&D can option for right of first refusal! Explore our innovations below and connect with U-M Innovation Partnerships to learn more!

Member Publications Supported By Digital Health Innovation

The digital health research we support with our members leads directly to novel scientific discoveries. See some our discoveries in the publications below.

TitleJournalAuthorsYear
Reducing Information and Selection Bias in EHR-Linked Biobanks via Genetics-Informed Multiple Imputation and Sample Weighting.medRxivSalvatore M, Kundu R, Du J, et al.2024
Risk Factors for Increased Opioid Use During Postoperative Intensive CareCritical Care ExplorationsGuichard L, Engoren MC, Li Y-J, et al.2024
Polygenic risk score for drug-induced long QT syndrome: independent validation in a real-world patient cohort.Pharmacogenet GenomicsLopez-Medina AI, Campos-Staffico AM, Chahal CAA, et al.2024
Dissecting the Genetic and Proteomic Risk Factors for DeliriummedRxivRaptis V, Bhak Y, Cannings TI, et al.2024
Genetic insight into the relationship between inflammatory bowel disease and Clostridioides difficile infection.mSphereCushing-Damm KC, Chen Y, Du X, et al.2024
Genetic Associations of Persistent Opioid Use After Surgery Point to OPRM1 but Not Other Opioid-Related Loci as the Main Driver of Opioid Use Disorder.Genet EpidemiolAnnis AC, Gunaseelan V, Smith AV, et al.2024
The role of genetically predicted serum iron levels on neurodegenerative and cardiovascular traitsSci RepBelbellaj W, Lona-Durazo F, Bodano C, et al.2024
Multivariate genomic analysis of 5 million people elucidates the genetic architecture of shared components of the metabolic syndrome.Nat GenetPark S, Kim S, Kim B, et al.2024
Sex-specific genetic architecture of blood pressure.Nat MedYang M-L, Xu C, Gupte T, et al.2024
Potential association of SULT2A1 and ABCG2 variant alleles with increased risk for palbociclib toxicity.PharmacogenomicsWang C, Hwang M, Paulson B, et al.2024
Genetic drivers of heterogeneity in type 2 diabetes pathophysiologyNatureSuzuki K, Hatzikotoulas K, Southam L, et al.2024
Polygenic Score for the Prediction of Postoperative Nausea and Vomiting: A Retrospective Derivation and Validation Cohort Study. AnesthesiologyAnesthesiologyDouville NJ, Bastarache L, He J, et al.2024
Investigating the association between gut microbiome and aortic aneurysm diseases: a bidirectional two-sample Mendelian randomization analysisFront Cell Infect MicrobiolSun Y, Dong H, Sun C, et al.2024
Associations Between Genetically Predicted Iron Status and Cardiovascular Disease Risk: A Mendelian Randomization StudyJ Am Heart Assoc.Barad A, Clark AG, Pressman EK, et al.2024
The Influence of Autoimmune Thyroid Diseases on Viral Pneumonia Development, Including COVID-19: A Two-Sample Mendelian Randomization StudyPathogensYi K, Tian M, Li X.2024
Connecting atrial fibrillation to digestive neoplasms: exploring mediation via ischemic stroke and heart failure in Mendelian randomization studiesFront OncolXu Z, Rao X, Xing Y, et al.2024
Risk of Toxicity From Topical 5-Fluorouracil Treatment in Patients Carrying DPYD Variant AllelesClin Pharmacol TherGranados J, Pasternak AL, Henry NL, et al.2024
Automated-detection of risky alcohol use prior to surgery using natural language processingAlcohol Clin Exp ResVydiswaran VGV, Strayhorn A, Weber K, et al.2024
Associations between metabolic hyperferritinaemia, fibrosis-promoting alleles and clinical outcomes in steatotic liver diseaseLiver IntSuresh D, Li A, Miller MJ, et al.2024
Risk scores for major bleeding from direct oral anticoagulants: comparing predictive performance in patients with atrial fibrillationRes Pract Thromb HaemostCampos-Staffico AM, Jacoby JP, Dorsch MP, et al.2024
Multi-Ancestry Polygenic Risk Scores for Venous Thromboembolism.medRxivJee YH, Thibord F, Dominguez A, et al.2024
Hemorrhoidal disease and its genetic association with depression, bipolar disorder, anxiety disorders, and schizophrenia: a bidirectional mendelian randomization studyHum GenomicsHuang Z, Huang J, Leung CK, et al.2024
Clinical associations with a polygenic predisposition to benign lower white blood cell countsNat CommunMosley JD, Shelley JP, Dickson AL, et al.2024
A framework for understanding selection bias in real-world healthcare dataJ R Stat Soc Ser AKundu R, Shi X, Morrison J, et al.2024
Incorporating functional annotation with bilevel continuous shrinkage for polygenic risk predictionBMC BioinformaticsZhuang Y, Kim NY, Fritsche LG, et al.2024
Plasma adiponectin levels and risk of heart failure, atrial fibrillation, aortic valve stenosis, and myocardial infarction: large-scale observational and Mendelian randomization evidenceCardiovasc ResNielsen MB, Çolak Y, Benn M, et al.2024
Genetic Liability to Posttraumatic Stress Disorder Symptoms and Its Association With Cardiometabolic and Respiratory OutcomesJAMA PsychiatryPathak GA, Singh K, Choi KW, et al.2024
Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK BiobankNat GenetOliveri A, Rebernick RJ, Kuppa A, et al.2024
To weight or not to weight? The effect of selection bias in 3 large electronic health record-linked biobanks and recommendations for practiceJ Am Med Inform AssocSalvatore M, Kundu R, Shi X, et al.2024
A genome-wide association study of susceptibility to upper urinary tract infectionsJ Infect DisFlatby HM, Ravi A, Liyanarachi KV, et al.2024
Assessing the Clinical Utility of Published Prostate Cancer Polygenic Risk Scores in a Large Biobank Data SetEur Urol OncolVince RA, Sun H, Singhal U, et al.2024
Association between nociplastic pain and premature endocrine therapy discontinuation in breast cancer patients.Breast Cancer Res TreatJoyce E, Carr G, Wang S, et al.2023
Confirmatory DPYD Testing in Patients Receiving Fluoropyrimidines Who are Suspected DPYD Variant Carriers Based on a Genetic Data RepositoryClin Pharmacol TherPasternak AL, Seda R, Lipa J, et al.2023
Genome-wide association study of thoracic aortic aneurysm and dissection in the Million Veteran ProgramNat GenetKlarin D, Devineni P, Sendamarai AK, et al.2023
Mendelian randomization study of thyroid function and anti-Müllerian hormone levelsFront EndocrinolLiang Z, Xu Z, Liu J.2023
Polygenic prediction of preeclampsia and gestational hypertension.Nat MedHonigberg MC, Truong B, Khan RR, et al.2023
Progression to cirrhosis is similar among all ages in nonalcoholic fatty liver disease, but liver-related events increase with ageHepatol CommunMiller MJ, Harding-Theobald E, DiBattista JV, et al.2023
Proteome‐Wide Mendelian Randomization Analysis Identified Potential Drug Targets for Atrial FibrillationJ Am Heart AssocWang X, Huang T, Jia J.2023
Major Genetic Risk Factors for Dupuytren’s Disease Are Inherited From NeandertalsMBEÅgren R, Patil S, Zhou X, et al.2023
Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architectureNat CommunHao X, Shao Z, Zhang N, et al.2023
Multi-ancestry meta-analysis identifies 5 novel loci for ischemic stroke and reveals heterogeneity of effects between sexes and ancestriesCell GenomSurakka I, Wu K-H, Hornsby W, et al.2023
Risk Variants in or Near ZBTB40 AND NFATC1 Increase the Risk of Both IBD and Adverse Bone Health Outcomes Highlighting Common Genetic Underpinnings Across Both DiseasesInflamm Bowel DisCushing KC, Chen Y, Du X, et al.2023
Epidemiologic Questionnaire (EPI-Q) – a scalable, app-based health survey linked to electronic health record and genotype dataEpidemiol HealthSalvatore M, Clark-Boucher D, Fritsche LG, et al.2023
A pilot genome-wide association study meta-analysis of gastroparesisUnited European Gastroenterol JTavares LC, Zheng T, Kwicklis M, et al.2023
PNPLA3 Risk Allele Association With ALT Response to Semaglutide TreatmentGastroenterologyUrias E, Tedesco NR, Oliveri A, et al.2023
Uncovering associations between pre-existing conditions and COVID-19 Severity: A polygenic risk score approach across three large biobanksPLoS GenetFritsche LG, Nam K, Du J, et al.2023
Predicting persistent opioid use after hand surgery: a machine learning approachPlast Reconstr SurgBaxter NB, Ho AZ, Byrd JN, et al.2023
Genome-wide association meta-analysis identifies 17 loci associated with nonalcoholic fatty liver diseaseNat GenetChen Y, Du X, Kuppa A, et al.2023
Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosusNat CommunKhunsriraksakul C, Li Q, Markus H, et al.2023
Evaluation of polygenic risk scores to differentiate between type 1 and type 2 diabetesGenet EpidemiolShoaib M, Ye Q, IglayReger H, et al.2023
PNPLA3 Genotype and Diabetes Identify Patients With Nonalcoholic Fatty Liver Disease at High Risk of Incident CirrhosisGastroenterologyChen VL, Oliveri A, Miller MJ, et al.2023
Identifying the prevalence of clinically actionable drug-gene interactions in a health system biorepository to guide pharmacogenetics implementation servicesClin Transl SciPasternak AL, Ward K, Irwin M, et al.2023
Association of ALDH1A1 Polymorphism With Toxicity From Cyclophosphamide TreatmentResearch SquareHwang M, Medley S, Shakeel F, et al.2022
Lack of association of CYP2B6 pharmacogenetics with cyclophosphamide toxicity in patients with cancerSupport Care CancerHwang M, Medley S, Shakeel F, et al.2022
Meta-analysis fine-mapping is often miscalibrated at single-variant resolutionCell GenomKanai M, Elzur R, Zhou W, et al.2022
Eight pharmacokinetic genetic variants are not associated with the risk of bleeding from direct oral anticoagulants in non-valvular atrial fibrillation patientsFront PharmacolCampos-Staffico AM, Dorsch MP, Barnes GD, et al.2022
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysisGenome BiolKanoni S, Graham SE, Wang Y, et al.2022
Differential and shared genetic effects on kidney function between diabetic and non-diabetic individualsCommun BiolWinkler TW, Rasheed H, Teumer A, et al.2022
COVID-19 and Thyroid Function: A Bi-Directional Two-Sample Mendelian Randomization StudyThyroidLi GH-Y, Tang C-M, Cheung C-L.2022
Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversityCell GenomTsuo K, Zhou W, Wang Y, et al.2022
The Phenotype-Genotype Reference Map: Improving biobank data science through replicationbioRxivBastarache L, Delozier S, Pandit A, et al.2022
The Michigan Genomics Initiative: A biobank linking genotypes and electronic clinical records in Michigan Medicine patientsCell GenomZawistowski M, Fritsche LG, Pandit A, et al.2022
Leveraging global multi-ancestry meta-analysis in the study of idiopathic pulmonary fibrosis geneticsCell GenomPartanen JJ, Häppölä P, Zhou W, et al.2022
Global Biobank Meta-analysis Initiative: Powering genetic discovery across human diseaseCell GenomZhou W, Kanai M, Wu K-HH, et al.2022
ExPRSweb: An online repository with polygenic risk scores for common health-related exposuresAm J Hum GenetMa Y, Patil S, Zhou X, et al.2022
Genetic variants associated with sepsisPLoS OneEngoren M, Jewell ES, Douville N, et al.2022
Impact of Pharmacogenetics on Intravenous Tacrolimus Exposure and Conversions to Oral TherapyTransplant Cell TherPasternak AL, Marcath LA, Li Y, et al.2022
A Substitution in the Glutathione Reductase Lowers Electron Leakage and Inflammation in Modern HumansSci AdvCoppo L, Mishra P, Siefert N, et al.2022
The Major Genetic Risk Factor for Severe COVID-19 Is Associated with Protection against HIVProc Natl Acad Sci USAZeberg H.2022
Predicting Persistent Opioid Use after Surgery Using Electronic Health Record and Patient-Reported DataSurgerySingh K, Murali A, Stevens H, et al.2022
A first update on mapping the human genetic architecture of COVID-19NaturePathak GA, Karjalainen J, Stevens C, et al.2022
Polygenic Liability to Depression Is Associated With Multiple Medical Conditions in the Electronic Health Record: Phenome-Wide Association Study of 46,782 IndividualsBiol PsychiatryFang Y, Fritsche LG, Mukherjee B, et al.2022
Assessing the Added Value of Linking Electronic Health Records to Improve the Prediction of Self-Reported COVID-19 Testing and DiagnosisPLoS OneClark-Boucher D, Boss J, Salvatore M, et al.2022
Polygenic Risk Prediction in DiverticulitisAnn SurgDe Roo AC, Chen Y, Du X, et al.2022
Genome-Wide Meta-Analysis of Iron Status Biomarkers and the Effect of Iron on All-Cause Mortality in HUNTCommun BiolMoksnes MR, Graham SE, Wu K-H, et al.2022
Hepatic decompensation is accelerated in patients with cirrhosis and alpha-1 antitrypsin Pi∗MZ genotypeJHEP RepChen VL, Burkholder DA, Moran IJ, et al2022
Inflammatory Bowel Disease Risk Variants Are Associated with an Increased Risk of Skin CancerInflamm Bowel DisCushing KC, Du X, Chen Y, et al.2022
The Construction of Multi-Ethnic Polygenic Risk Score Using Transfer LearningmedRxivZhao Z, Fritsche LG, Smith JA, et al.2022
SLCO1B3 Polymorphisms and Clinical Outcomes in Kidney Transplant Recipients Receiving MycophenolatePharmacogenomicsSchumacher L, Fang F, Kidwell KM, et al.2021
Plasma Cortisol and Risk of Atrial Fibrillation: A Mendelian Randomization StudyJ Clin Endocrinol MetabLarsson SC, Lee W-H, Burgess S, et al.2021
The Power of Genetic Diversity in Genome-Wide Association Studies of LipidsNatureGraham SE, Clarke SL, Wu K-HH, et al.2021
On Cross-Ancestry Cancer Polygenic Risk ScoresPLoS GenetFritsche LG, Ma Y, Zhang D, et al.2021
False Discovery Rates for Genome-Wide Association Tests in Biobanks with Thousands of PhenotypesResearch SquareAnnis A, Pandit A, LeFaive J, et al.2021
Exposure and risk factors for COVID-19 and the impact of staying home on Michigan residentsPLoS OneWu K-HH, Hornsby WE, Klunder B, et al.2021
A powerful subset-based method identifies gene set associations and improves interpretation in UK BiobankAm J Hum GenetDutta D, VandeHaar P, Fritsche LG, et al.2021
A survey of functional dyspepsia in 361,360 individuals: Phenotypic and genetic cross‐disease analysesNeurogastroenterol MotilGarcia-Etxebarria K, Carbone F, Teder-Laving M, et al.2021
Genetic association studies of fibromuscular dysplasia identify new risk loci and shared genetic basis with more common vascular diseasesNat CommunGeorges A, Yang M-L, Berrandou T-E, et al.2021
Mapping the human genetic architecture of COVID-19NatureNiemi MEK, Karjalainen J, Liao RG, et al.2021
Disclosure of clinically actionable genetic variants to thoracic aortic dissection biobank participantsBMC Med GenomicsBeil A, Hornsby W, Uhlmann WR, et al.2021
Genome-wide analysis of 944 133 individuals provides insights into the etiology of haemorrhoidal diseaseGutZheng T, Ellinghaus D, Juzenas S, et al.2021
Regulatory variants in TCF7L2 are associated with thoracic aortic aneurysmAm J Hum GenetRoychowdhury T, Lu H, Hornsby WE, et al.2021
Genome-Wide Association Study of Pelvic Organ Prolapse Using the Michigan Genomics InitiativeFemale Pelvic Med Reconstr SurgCox CK, Pandit A, Zawistowski M, et al.2021
Allele-specific variation at APOE increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer’s disease and myocardial infarctionHum Mol GenetPalmer ND, Kahali B, Kuppa A, et al.2021
Patients carrying DPYD variant alleles have increased risk of severe toxicity and related treatment modifications during fluoropyrimidine chemotherapyPharmacogenomicsShakeel F, Fang F, Kwon JW, et al.2021
Why are rare variants hard to impute? Coalescent models reveal theoretical limits in existing algorithmsGeneticsSi Y, Vanderwerff B, Zöllner S2021
Phenotype risk scores (PheRS) for pancreatic cancer using time-stamped electronic health record data: Discovery and validation in two large biobanksJ Biomed InformSalvatore M, Beesley LJ, Fritsche LG, et al.2021
Genetic mutations associated with susceptibility to perioperative complications in a longitudinal biorepository with integrated genomic and electronic health recordsBr J AnaesthDouville NJ, Kheterpal S, Engoren M, et al.2020
Use of a Polygenic Risk Score Improves Prediction of Myocardial Injury After Non-Cardiac SurgeryCirc Genom Precis MedDouville NJ, Surakka I, Leis A, et al.2020
GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancerNat CommunZhou W, Brumpton B, Kabil O, et al.2020
Loss-of-function genomic variants highlight potential therapeutic targets for cardiovascular diseaseNat CommunNielsen JB, Rom O, Surakka I, et al.2020
Chromosome 1q21. 2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarctionNat CommunSaw J, Yang M-L, Trinder M, et al.2020
LabWAS: Novel findings and study design recommendations from a meta-analysis of clinical labs in two independent biobanksPLoS GenetGoldstein JA, Weinstock JS, Bastarache LA, et al.2020
Statistical inference for association studies using electronic health records: handling both selection bias and outcome misclassificationBiometricsBeesley LJ, Mukherjee B2020
Novel score test to increase power in association test by integrating external controlsGenet EpidemiolLi Y, Lee S2020
Cancer PRSweb: An Online Repository with Polygenic Risk Scores for Major Cancer Traits and Their Evaluation in Two Independent BiobanksAm J Hum GenetFritsche LG, Patil S, Beesley LJ, et al.2020
An analytic framework for exploring sampling and observation process biases in genome and phenome-wide association studies using electronic health recordsStat MedBeesley LJ, Fritsche LG, Mukherjee B2020
Interaction analysis under misspecification of main effects: Some common mistakes and simple solutionsStat MedZhang M, Yu Y, Wang S, et al.2020
The emerging landscape of health research based on biobanks linked to electronic health records: Existing resources, statistical challenges, and potential opportunitiesStat MedBeesley LJ, Salvatore M, Fritsche LG, et al.2020
Genetic variants that associate with cirrhosis have pleiotropic effects on human traitsLiver IntChen VL, Chen Y, Du X, et al.2020
Heritability of the Fibromyalgia Phenotype Varies by AgeArthritis RheumatolDutta D, Brummett CM, Moser SE, et al.2020
Estimation of DNA contamination and its sources in genotyped samplesGenet EpidemiolZajac GJM, Fritsche LG, Weinstock JS, et al.2019
Meta-MultiSKAT: Multiple phenotype meta-analysis for region-based association testGenet EpidemiolDutta D, Gagliano Taliun SA, Weinstock JS, et al.2019
Body Composition and Genetic Lipodystrophy Risk Score Associate With Nonalcoholic Fatty Liver Disease and Liver FibrosisHepatol CommunChen VL, Wright AP, Halligan B, et al.2019
Health Care Burden Associated with Outpatient Opioid Use Following Inpatient or Outpatient SurgeryJ Manag Care Spec PharmBrummett CM, England C, Evans-Shields J, et al.2019
Exploring various polygenic risk scores for skin cancer in the phenomes of the Michigan genomics initiative and the UK Biobank with a visual catalog: PRSWebPLoS GenetFritsche LG, Beesley LJ, VandeHaar P, et al.2019
Sex-specific and pleiotropic effects underlying kidney function identified from GWAS meta-analysisNat CommunGraham SE, Nielsen JB, Zawistowski M, et al.2019
Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetesNat CommunGusarova V, O’Dushlaine C, Teslovich TM, et al.2018
Biobank-driven genomic discovery yields new insight into atrial fibrillation biologyNat GenetNielsen JB, Thorolfsdottir RB, Fritsche LG, et al.2018
Genome-wide association analyses identify 39 new susceptibility loci for diverticular diseaseNat GenetMaguire LH, Handelman SK, Du X, et al.2018
Association of Polygenic Risk Scores for Multiple Cancers in a Phenome-wide Study: Results from The Michigan Genomics InitiativeAm J Hum GenetFritsche LG, Gruber SB, Wu Z, et al.2018
Association of Rare Predicted Loss-of-Function Variants in Cellular Pathways with Sub-Phenotypes in Age-Related Macular DegenerationOphthalmologyPietraszkiewicz A, van Asten F, Kwong A, et al.2018
Prevalence of Preoperative Opioid Use and Characteristics Associated With Opioid Use Among Patients Presenting for SurgeryJAMA SurgHilliard PE, Waljee J, Moser S, et al.2018
Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac DevelopmentAm J Hum GenetNielsen JB, Fritsche LG, Zhou W, et al.2018
Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valveNat CommunYang B, Zhou W, Jiao J, et al.2017
A Fast and Accurate Algorithm to Test for Binary Phenotypes and Its Application to PheWASAm J Hum GenetDey R, Schmidt EM, Abecasis GR, et al.2017